Dear Leslie Tanner,

I referred your question to one of today's foremost Jewish historians, Rabbi Berel Wein. He said, that as far as he is aware, this information is not known. What he could tell me though, was that the first Jews to settle in what is now the US were Sephardic Jews who came from the West Indies in the 1650's. The first family to settle in Philadelphia (whether they were the first in the US, Rabbi Wein did not know) was the Seixas family.